To explore what is impact of the instruction model integrated with WIKI platform and computer collaborative learning theory on students’ CET-4 grades, an instance is devised here to simulate the application of this instruction model in CET-4 learning process of students in any majors rather than English of university. First of all, this paper makes a general overview on WIKI platform and computer collaborative instruction model, then describes the design of didactical activities and function modules on WIKI platform; based on the content of courses, a contrast experiment is cited to help analyze and compare Pre-test and Post-test CET-4 grades of students as chosen in experiment class and in control class. Not only that, the application effect of WIKI platform in the university education is exposed to us after the questionnaire survey and face-to-face interviews are made on the respondents. This study results reveal the instruction effect of collaborative learning model for CET-4 under the WIKI environment, and emerges as a theoretic basis for accelerating the diversified development of university English pedagogy in China.