In view of the current situation that it’s imperative for literature majors in colleges and universities to undergo reforms, this paper studies the innovation of teaching methods of literature majors under the conditions of informationization. First of all, it analyzes the problems of current literature teaching; then, information technologies that can be used at the present stage of higher education are listed; at last, it proposes a series of innovation methods for literature major teaching based on higher education informatization, and some students from the Chinese Language and Literature major of a college are taken as examples to conduct an empirical study. A comparative analysis of the learning effects of college students of different grades shows the effectiveness of the teaching innovation methods proposed in this paper. The research results of this paper not only propose new teaching methods, but also provide a useful reference for the transformation of the current development concept of higher education.