Under the background of the knowledge economy era, colleges and universities of higher vocational education should take cultivating interdisciplinary talents with knowledge, skills, ability and quality for the society as the teaching objective, innovate the development mode and update the educational concept. Based on the important significance of innovative integrated development of higher vocational technical and humanistic education, this article takes social interaction theory as the breakthrough point, combines with the status quo of integrated development of technical and humanistic education, and analyzes the dilemma of integrated development in such a situation from different perspectives. Corresponding improving strategies have been put forward in three aspects: premise and foundation, core conditions and guarantee mechanism, so as to build an innovative mode of integrated development of technical and humanistic education in higher vocational education.