Innovation serves as a primary motivity to lead the development of the education cause. Local colleges and universities shoulder a critical mission of foothold on and serve the local areas, and play a vital role in the development of the local economy. They should integrate local resources to do a good job on the innovative talent cultivation for the purpose of delivering some innovative talents for local economic development. This paper, based on the survey conducted for employers and graduates, proposes a CDIO-based efficient innovative talent cultivation model framework and the curriculum system program which integrated the Conceive-Design -Implement-Operate (CDIO) concept thereof. The idea in this paper has a positive significance for future studies on the innovative talent cultivation model.