Although recent studies have provided some explanation about the relationship between difficulties in emotion regulation and aggression in adolescence, the role of intervening variables in this connection has been ignored. The purpose of this research was to understand the relationship between adolescents’ emotion regulation and aggression and to focus on the mediator function of social problem-solving and anger control. Participants comprised 413 adolescents (252 females and 161 males; mean age 15 years). The findings provided evidence for the partial mediator role of anger control and social problem-solving. The author discusses the theoretical and practical implications of these results in this study.