Higher education is an important base for scientific research and personnel training, and the upgrading of industrial structure is inseparable from advanced technology and high-quality talents. Based on the research on the correlation between education input and the upgrading of industrial structure under the background of Beijing-Tianjin-Hebei coordinated development, this paper analyzes the present situation of higher education input-output and the upgrading of industrial structure in Beijing-Tianjin-Hebei region by means of statistical analysis. By introducing the method of regression analysis, this paper makes an empirical analysis of the correlation between the input-output of education and the optimization and upgrading of industrial structure. The results show that the input of education can support and lead the upgrading of industrial structure. The upgrading of industrial structure has feedback and promotion effect on educational investment. This research has certain guiding significance to promote the positive interaction between education input and upgrading of industrial structure in Beijing-Tianjin-Hebei region, and to realize the coordinated development in BeijingTianjin-Hebei region.