As a new teaching mode that changes the traditional roles of teachers and students, flipped classroom is a classroom teaching form which is being explored in the teaching reform. In this paper, we study the teaching of the course based on MOOC, and explore how to use the course resources of MOOC to apply to the teaching of flipped classroom. On this basis, through questionnaire survey, the current situation of MOOC quality monitoring and guarantee in some universities are investigated. It is found that the quality standard of MOOC course construction is not perfect and the teaching quality monitoring and guarantee system is not perfect. In view of the existing problems, a quality monitoring and security system for flipped classroom based on MOOC is constructed.