The promotion of new teaching models like MOOC and SPOC has spurred an exponential growth in the amount of teaching resources. However, the current university education system fails to respond to the changing scenario. The curriculum teaching is in lack of penitence, timeliness, advanced methods and diverse evaluation means. Against this backdrop, this paper draws the merits of big data and ontology theory, and creates an automatic curriculum ontology construction technology. Coupled with new teaching models like SPOC and flipped classroom, the author developed a new SPOC-based flipped classroom teaching model driven by curriculum ontology. Then, the new teaching model was applied in the design of a teaching plan, and verified in the course of Electronic Commerce. After a semester of teaching practice, the results show that the proposed method is more efficient and universal than the traditional ontology construction method; more importantly, our method promotes the teaching effect and enhances the students’ overall abilities like autonomous learning, collaborative research. The research findings provide reference for hybrid teaching in the future, and shed new light on the reform for individualized and diversified university curriculum teaching.