This paper builds a co-education performance mechanism model with universities’ overall strength, quality of students and organizational management as independent variables, talent co-education performance in Fujian and Taiwan universities as dependent variables, and the co-education extent as intervening variable. A questionnaire survey is conducted to access truthful data for empirical study carried out by using the structural equation model. The findings reveal that the overall strength, the quality of students, the organizational management all have a significantly positive correlation with the talent co-education performance in Fujian and Taiwan universities, where the co-education extent plays an intermediation effect. To enhance the strength of universities, it is required to select appropriate partners, intensify the policy support, macroeconomic regulation and control of the government, imbue students with right ideas, motivate them in learning, blend co-education concepts into pedagogical practices, rationalize the management system; build up communication channels and facilitate a deep integration.