At present, China has stepped into the era of the economy of everyone and mass entrepreneurship. Colleges and universities as the carrier of the era of mass entrepreneurship, and innovation and entrepreneurship education presents increasingly important significance. Based on the data of 9 colleges and universities in Jiangsu Province in 2016, the index system of innovation and entrepreneurship education capacity is established, and the model is established by entropy TOPSIS method. The empirical analysis is carried out on the level of innovation and entrepreneurship education capacity of 9 colleges and universities. The results show that the main factors that influence the innovative entrepreneurship education capacity include the number of publications published, the number of patents authorized, the entrepreneurial plan contest and the university science park. The resource allocation ability of colleges and universities is different, and the input-output ratio is obviously different.