The present research effort determined the academic performance of higher education sector of Iraq that is prejudiced by the various leadership factors. This study incorporated the teachers’ self-efficacy and teachers’ leadership as mediators between transformational leadership and academic performance. The study was conducted on the higher education sector of Iraq and data was collected through questionnaire by employing the simple random sampling and was assessed by utilizing the Smart-PLS 4.0 to test the relationship between proposed variables of the research framework. The study revealed that transformational leadership influence the academic performance, teachers’ self-efficacy and teachers’ leadership. The hypotheses H1, H2 and H4 reported as statistically significant, however the direct relationships between teachers’ self-efficacy and academic performance, the relationship between teachers’ leadership and academic performance found to be insignificant that hypotheses H3 and H5 were rejected. Surprisingly, the teachers’ self-efficacy and teachers’ leadership significant mediates the relationship between transformational leadership and academic performance, they hypotheses H6 and H7 were accepted. The study suggests to adopt the transformational leadership style and focuses to ensure the develop the teachers’ self-efficacy, develop the leadership skills among teachers in order to ensure the academic performance. The future research avenue is given at the end of the present paper.