The era of multi-culture with popular We Media has provided opportunities and challenges for ideological and political education in colleges and universities. This paper focuses on the construction of ideological and political education in colleges and universities under the evolution of We Media communication mode, mainly in three aspects: first of all, it combs out the basic theoretical problems of ideological construction in colleges and universities in the era of We Media; secondly, the challenges and opportunities faced by the ideology of colleges and universities in the era of We Media are discussed in detail; finally, the paper probes into the path innovation of ideological construction in colleges and universities in the era of We Media. With the methods of literature investigation, observation and concept analysis, this paper attempts to explore the new path and mode of ideological and political education and evaluation in colleges and universities in the era of We Media, so as to do a good job in the construction of ideological position of colleges and universities.