In view of the problem that the cooperation between higher vocational schools and enterprises is not thorough enough, this paper demonstrates the necessity of cooperation between higher vocational schools and enterprises from the perspective of “construction of technical school” theory. Through the construction of higher vocational school-enterprise cooperative synergetic system model and analysis of its synergistic factors, this paper analyzes the internal order parameters and external control parameters related to school-enterprise cooperation. Under the concept of full-value chain, it uses enterprise colleges as the entry point to find out the improvement measures for deepening the cooperation between higher vocational schools and enterprises, and to promote the emergence of the synergistic effect of “1+1>2” in the cooperation between schools and enterprises.