New media technology has been widely used in the teaching of various disciplines in colleges and universities, which is a significant change and innovative development of the traditional teaching mode. This paper investigates the current situation of vocabulary teaching in college English courses, and analyzes the main problems, such as single teaching method, lack of interaction in the teaching process, lack of context in vocabulary training, and students’ low evaluation of the course. In view of the above problems, based on the characteristics of new media technology, this paper explores the application path of new media technology in college English vocabulary teaching, as well as the problems that should be paid attention to in order to improve the application effect. Through the research, we can promote the reform of college English vocabulary teaching, change the attitude and evaluation of college students to vocabulary teaching, stimulate their initiative to learn vocabulary, and improve the quality of college English vocabulary teaching.